Logan paul xfer serum skin11/3/2023 Our findings demonstrate the role of the microbiota in establishment of a specific myeloid cell subset expressing CD169 in the skin and provide evidence of a specific mechanism by which this subset protects against bacterial skin infection. CD169 + macrophages mediated the recruitment of γδ T cells as well as the activation of γδ T cells via interleukin (IL)-23. The absence of CD169 + macrophages resulted in increased bacterial burden and impaired immune responses against Staphylococcus aureus skin infection. The decrease in type I IFN signaling was closely related to the presence of microbiota and macrophage-specific marker CD169. Transcriptomic analysis revealed that type I interferon (IFN) signaling was down-regulated in the skin of germ-free mice compared to that in specific pathogen-free mice. The effects of the gut microbiota on myeloid cells remote from the gut, especially the skin remain unclear. Microbiota is essential to the development and functional maturation of the immune system. 2Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea. Young Joon Park 1,2 Byeong Hoon Kang 1 Hyun-Jin Kim 1 Ji Eun Oh 1 Heung Kyu Lee 1*
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